Synthesis of polymeric prodrugs of chlorphenesin with.
The acute dose skin irritation potential of 0.3% chlorphenesin (in water) was evaluated using 25 subjects (20 females, 5 males; 19 to 62 years old). An occlusive patch containing the test substance (0.1 ml) was applied to the back of each subject for 48 h. Reactions were scored 20 minutes after patch removal.
Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.
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Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines. Other central effects include sedation, anxiolysis, and dizziness.
Chlorphenesin carbamate is the carbamate ester of the primary hydroxy group of chlorphenesin. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm. It has a role as a muscle relaxant. It is a carbamate ester, a member of monochlorobenzenes and a secondary alcohol.
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